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Evolutionary drivers of thermoadaptation in enzyme catalysis
With early life likely to have existed in a hot environment, enzymes had to cope with an inherent drop in catalytic speed caused by lowered temperature. Here we characterize the molecular mechanisms underlying thermoadaptation of enzyme catalysis in adenylate kinase using ancestral sequence reconstr...
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| Publié dans: | Science |
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| Auteurs principaux: | , , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2016
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5649376/ https://ncbi.nlm.nih.gov/pubmed/28008087 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aah3717 |
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