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Probing the Transition State in Enzyme Catalysis by High-Pressure NMR Dynamics
Protein conformational changes are frequently essential for enzyme catalysis, and in several cases, shown to be the limiting factor for overall catalytic speed. However, a structural understanding of corresponding transition states, needed to rationalize the kinetics, remains obscure due to their fl...
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| Publicado no: | Nat Catal |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7063682/ https://ncbi.nlm.nih.gov/pubmed/32159076 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41929-019-0307-6 |
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