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Rescue of conformational dynamics in enzyme catalysis by directed evolution
Rational design and directed evolution have proved to be successful approaches to increase catalytic efficiencies of both natural and artificial enzymes. Protein dynamics is recognized as important, but due to the inherent flexibility of biological macromolecules it is often difficult to distinguish...
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| Pubblicato in: | Nat Commun |
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| Autori principali: | , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Publishing Group UK
2018
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5883053/ https://ncbi.nlm.nih.gov/pubmed/29615624 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-03562-9 |
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