Evolutionary drivers of thermoadaptation in enzyme catalysis

With early life likely to have existed in a hot environment, enzymes had to cope with an inherent drop in catalytic speed caused by lowered temperature. Here we characterize the molecular mechanisms underlying thermoadaptation of enzyme catalysis in adenylate kinase using ancestral sequence reconstr...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Science
Prif Awduron: Nguyen, Vy, Wilson, Christopher, Hoemberger, Marc, Stiller, John B., Agafonov, Roman V., Kutter, Steffen, English, Justin, Theobald, Douglas L., Kern, Dorothee
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2016
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5649376/
https://ncbi.nlm.nih.gov/pubmed/28008087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aah3717
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