Allosteric modulation of a human protein kinase with monobodies

Despite being the subject of intense effort and scrutiny, kinases have proven to be consistently challenging targets in inhibitor drug design. A key obstacle has been promiscuity and consequent adverse effects of drugs targeting the ATP binding site. Here we introduce an approach to controlling kina...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Proc Natl Acad Sci U S A
Main Authors: Zorba, Adelajda, Nguyen, Vy, Koide, Akiko, Hoemberger, Marc, Zheng, Yuejiao, Kutter, Steffen, Kim, Chansik, Koide, Shohei, Kern, Dorothee
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2019
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6628680/
https://ncbi.nlm.nih.gov/pubmed/31239342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1906024116
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