Učitavanje...
Allosteric modulation of a human protein kinase with monobodies
Despite being the subject of intense effort and scrutiny, kinases have proven to be consistently challenging targets in inhibitor drug design. A key obstacle has been promiscuity and consequent adverse effects of drugs targeting the ATP binding site. Here we introduce an approach to controlling kina...
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| Izdano u: | Proc Natl Acad Sci U S A |
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| Glavni autori: | , , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
National Academy of Sciences
2019
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6628680/ https://ncbi.nlm.nih.gov/pubmed/31239342 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1906024116 |
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