Dynamics of human protein kinase Aurora A linked to drug selectivity

Protein kinases are major drug targets, but the development of highly-selective inhibitors has been challenging due to the similarity of their active sites. The observation of distinct structural states of the fully-conserved Asp-Phe-Gly (DFG) loop has put the concept of conformational selection for...

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Опубликовано в: :eLife
Главные авторы: Pitsawong, Warintra, Buosi, Vanessa, Otten, Renee, Agafonov, Roman V, Zorba, Adelajda, Kern, Nadja, Kutter, Steffen, Kern, Gunther, Pádua, Ricardo AP, Meniche, Xavier, Kern, Dorothee
Формат: Artigo
Язык:Inglês
Опубликовано: eLife Sciences Publications, Ltd 2018
Предметы:
Cancer Biology
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6054532/
https://ncbi.nlm.nih.gov/pubmed/29901437
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.36656
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