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Dynamics of human protein kinase Aurora A linked to drug selectivity
Protein kinases are major drug targets, but the development of highly-selective inhibitors has been challenging due to the similarity of their active sites. The observation of distinct structural states of the fully-conserved Asp-Phe-Gly (DFG) loop has put the concept of conformational selection for...
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| 發表在: | eLife |
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| Main Authors: | , , , , , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
eLife Sciences Publications, Ltd
2018
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6054532/ https://ncbi.nlm.nih.gov/pubmed/29901437 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.36656 |
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