Učitavanje...
Using ancient protein kinases to unravel a modern cancer drug’s mechanism
Macromolecular function is rooted in energy landscapes, where sequence determines not a single structure but an ensemble of conformations. Hence, evolution modifies a protein’s function by altering its energy landscape. Here, we recreate the evolutionary pathway between two modern human oncogenes, S...
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| Izdano u: | Science |
|---|---|
| Glavni autori: | , , , , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2015
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4405104/ https://ncbi.nlm.nih.gov/pubmed/25700521 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aaa1823 |
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