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Mechanism of activating mutations and allosteric drug inhibition of the phosphatase SHP2
Protein tyrosine phosphatase SHP2 functions as a key regulator of cell cycle control, and activating mutations cause several cancers. Here, we dissect the energy landscape of wild-type SHP2 and the oncogenic mutation E76K. NMR spectroscopy and X-ray crystallography reveal that wild-type SHP2 exchang...
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| Publicado en: | Nat Commun |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Nature Publishing Group UK
2018
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6207724/ https://ncbi.nlm.nih.gov/pubmed/30375376 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-06814-w |
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