Allosteric modulation of a human protein kinase with monobodies

Despite being the subject of intense effort and scrutiny, kinases have proven to be consistently challenging targets in inhibitor drug design. A key obstacle has been promiscuity and consequent adverse effects of drugs targeting the ATP binding site. Here we introduce an approach to controlling kina...

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Foilsithe in:Proc Natl Acad Sci U S A
Main Authors: Zorba, Adelajda, Nguyen, Vy, Koide, Akiko, Hoemberger, Marc, Zheng, Yuejiao, Kutter, Steffen, Kim, Chansik, Koide, Shohei, Kern, Dorothee
Formáid: Artigo
Teanga:Inglês
Foilsithe: National Academy of Sciences 2019
Ábhair:
Biological Sciences
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6628680/
https://ncbi.nlm.nih.gov/pubmed/31239342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1906024116
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