The energy landscape of adenylate kinase during catalysis

Kinases perform phosphoryl-transfer reactions in milliseconds; without enzymes, these reactions would take about 8000 years under physiological conditions. Despite extensive studies, a comprehensive understanding of kinase energy landscapes, including both chemical and conformational steps, is lacki...

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Detalhes bibliográficos
Publicado no:Nat Struct Mol Biol
Main Authors: Kerns, S. Jordan, Agafonov, Roman V., Cho, Young-Jin, Pontiggia, Francesco, Otten, Renee, Pachov, Dimitar V., Kutter, Steffen, Phung, Lien A., Murphy, Padraig N., Thai, Vu, Alber, Tom, Hagan, Michael F., Kern, Dorothee
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4318763/
https://ncbi.nlm.nih.gov/pubmed/25580578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2941
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