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The energy landscape of adenylate kinase during catalysis
Kinases perform phosphoryl-transfer reactions in milliseconds; without enzymes, these reactions would take about 8000 years under physiological conditions. Despite extensive studies, a comprehensive understanding of kinase energy landscapes, including both chemical and conformational steps, is lacki...
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| 發表在: | Nat Struct Mol Biol |
|---|---|
| Main Authors: | , , , , , , , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2015
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4318763/ https://ncbi.nlm.nih.gov/pubmed/25580578 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2941 |
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