A synthetic ion transporter that disrupts autophagy and induces apoptosis by perturbing cellular chloride concentrations

Perturbations in cellular chloride concentrations can affect cellular pH and autophagy and lead to the onset of apoptosis. With this in mind, synthetic ion transporters have been used to disturb cellular ion homeostasis and thereby induce cell death; however, it is not clear whether synthetic ion tr...

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Veröffentlicht in:Nat Chem
Hauptverfasser: Busschaert, Nathalie, Park, Seong-Hyun, Baek, Kyung-Hwa, Choi, Yoon Pyo, Park, Jinhong, Howe, Ethan N. W., Hiscock, Jennifer R., Karagiannidis, Louise E., Marques, Igor, Félix, Vítor, Namkung, Wan, Sessler, Jonathan L., Gale, Philip A., Shin, Injae
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5648535/
https://ncbi.nlm.nih.gov/pubmed/28644464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchem.2706
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