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A synthetic ion transporter that disrupts autophagy and induces apoptosis by perturbing cellular chloride concentrations

Perturbations in cellular chloride concentrations can affect cellular pH and autophagy and lead to the onset of apoptosis. With this in mind, synthetic ion transporters have been used to disturb cellular ion homeostasis and thereby induce cell death; however, it is not clear whether synthetic ion tr...

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Dades bibliogràfiques
Publicat a:Nat Chem
Autors principals: Busschaert, Nathalie, Park, Seong-Hyun, Baek, Kyung-Hwa, Choi, Yoon Pyo, Park, Jinhong, Howe, Ethan N. W., Hiscock, Jennifer R., Karagiannidis, Louise E., Marques, Igor, Félix, Vítor, Namkung, Wan, Sessler, Jonathan L., Gale, Philip A., Shin, Injae
Format: Artigo
Idioma:Inglês
Publicat: 2017
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5648535/
https://ncbi.nlm.nih.gov/pubmed/28644464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchem.2706
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