Squaramide-based synthetic chloride transporters activate TFEB but block autophagic flux

Cystic fibrosis is a disease caused by defective function of a chloride channel coupled to a blockade of autophagic flux. It has been proposed to use synthetic chloride transporters as pharmacological agents to compensate insufficient chloride fluxes. Here, we report that such chloride anionophores...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Cell Death Dis
मुख्य लेखकों: Zhang, Shaoyi, Wang, Yan, Xie, Wei, Howe, Ethan N. W., Busschaert, Nathalie, Sauvat, Allan, Leduc, Marion, Gomes-da-Silva, Lígia C., Chen, Guo, Martins, Isabelle, Deng, Xiaxing, Maiuri, Luigi, Kepp, Oliver, Soussi, Thierry, Gale, Philip A., Zamzami, Naoufal, Kroemer, Guido
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: Nature Publishing Group UK 2019
विषय:
Article
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC6411943/
https://ncbi.nlm.nih.gov/pubmed/30858361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-019-1474-8
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