Squaramide-based synthetic chloride transporters activate TFEB but block autophagic flux

Cystic fibrosis is a disease caused by defective function of a chloride channel coupled to a blockade of autophagic flux. It has been proposed to use synthetic chloride transporters as pharmacological agents to compensate insufficient chloride fluxes. Here, we report that such chloride anionophores...

Full description

Saved in:
Bibliographic Details
Published in:Cell Death Dis
Main Authors: Zhang, Shaoyi, Wang, Yan, Xie, Wei, Howe, Ethan N. W., Busschaert, Nathalie, Sauvat, Allan, Leduc, Marion, Gomes-da-Silva, Lígia C., Chen, Guo, Martins, Isabelle, Deng, Xiaxing, Maiuri, Luigi, Kepp, Oliver, Soussi, Thierry, Gale, Philip A., Zamzami, Naoufal, Kroemer, Guido
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2019
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6411943/
https://ncbi.nlm.nih.gov/pubmed/30858361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-019-1474-8
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items