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TFEB activation protects against cardiac proteotoxicity via increasing autophagic flux

Insufficient lysosomal removal of autophagic cargoes in cardiomyocytes has been suggested as a main cause for the impairment of the autophagic-lysosomal pathway (ALP) in many forms of heart disease including cardiac proteinopathy and may play an important pathogenic role; however, the molecular basi...

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Dades bibliogràfiques
Publicat a:J Mol Cell Cardiol
Autors principals: Pan, Bo, Zhang, Hanming, Cui, Taixing, Wang, Xuejun
Format: Artigo
Idioma:Inglês
Publicat: 2017
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5656243/
https://ncbi.nlm.nih.gov/pubmed/28993153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2017.10.003
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