A synthetic ion transporter that disrupts autophagy and induces apoptosis by perturbing cellular chloride concentrations

Perturbations in cellular chloride concentrations can affect cellular pH and autophagy and lead to the onset of apoptosis. With this in mind, synthetic ion transporters have been used to disturb cellular ion homeostasis and thereby induce cell death; however, it is not clear whether synthetic ion tr...

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Udgivet i:Nat Chem
Main Authors: Busschaert, Nathalie, Park, Seong-Hyun, Baek, Kyung-Hwa, Choi, Yoon Pyo, Park, Jinhong, Howe, Ethan N. W., Hiscock, Jennifer R., Karagiannidis, Louise E., Marques, Igor, Félix, Vítor, Namkung, Wan, Sessler, Jonathan L., Gale, Philip A., Shin, Injae
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5648535/
https://ncbi.nlm.nih.gov/pubmed/28644464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchem.2706
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