Saposin B Binds the Lipofuscin Bisretinoid A2E and Prevents its Enzymatic and Photooxidation

Vitamin A based bisretinoid accumulation is a major focus in the study of macular degeneration. Whether specific endogenous lysosomal proteins can bind A2E, a pronounced bisretinoid in lipofuscin granules in retinal pigment epithelial cells, and interfere with enzymatic or photoinduced oxidation of...

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Bibliographic Details
Published in:ChemPhotoChem
Main Authors: Tinklepaugh, Jay, Smith, Britannia M., Nie, Yan, Moody, Kelsey, Grohn, Kris, Bou-Abdallah, Fadi, Doyle, Robert P.
Format: Artigo
Language:Inglês
Published: 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5646234/
https://ncbi.nlm.nih.gov/pubmed/29057298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cptc.201700039
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