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Fenretinide binding to the lysosomal protein saposin D alters ceramide solubilization and hydrolysis
Fenretinide is a synthetic retinoid pharmaceutical linked to ceramide build-up in vivo. Saposin D is an intralysosomal protein necessary for ceramide binding/degradation. We show, via electronic absorption spectroscopy, fluorescence spectroscopy, and ceramide hydrolysis assays, that fenretinide is b...
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| Publicado no: | RSC Med Chem |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Royal Society of Chemistry
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7513591/ https://ncbi.nlm.nih.gov/pubmed/33479697 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d0md00182a |
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