Fenretinide Prevents Lipid-induced Insulin Resistance by Blocking Ceramide Biosynthesis

Fenretinide is a synthetic retinoid that is being tested in clinical trials for the treatment of breast cancer and insulin resistance, but its mechanism of action has been elusive. Recent in vitro data indicate that fenretinide inhibits dihydroceramide desaturase, an enzyme involved in the biosynthe...

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Bibliografiske detaljer
Main Authors: Bikman, Benjamin T., Guan, Yuguang, Shui, Guanghou, Siddique, M. Mobin, Holland, William L., Kim, Ji Yun, Fabriàs, Gemma, Wenk, Markus R., Summers, Scott A.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2012
Fag:
Lipids
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3366851/
https://ncbi.nlm.nih.gov/pubmed/22474281
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.359950
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