Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid–induced ceramide biosynthesis in mice

Obesity is associated with an enhanced inflammatory response that exacerbates insulin resistance and contributes to diabetes, atherosclerosis, and cardiovascular disease. One mechanism accounting for the increased inflammation associated with obesity is activation of the innate immune signaling path...

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Detalhes bibliográficos
Main Authors: Holland, William L., Bikman, Benjamin T., Wang, Li-Ping, Yuguang, Guan, Sargent, Katherine M., Bulchand, Sarada, Knotts, Trina A., Shui, Guanghou, Clegg, Deborah J., Wenk, Markus R., Pagliassotti, Michael J., Scherer, Philipp E., Summers, Scott A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3083776/
https://ncbi.nlm.nih.gov/pubmed/21490391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI43378
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