Saturated and unsaturated fat induce hepatic insulin resistance independently of TLR-4 signaling and ceramide synthesis in vivo

Hepatic insulin resistance is a principal component of type 2 diabetes, but the cellular and molecular mechanisms responsible for its pathogenesis remain unknown. Recent studies have suggested that saturated fatty acids induce hepatic insulin resistance through activation of the toll-like receptor 4...

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Detalhes bibliográficos
Main Authors: Galbo, Thomas, Perry, Rachel J., Jurczak, Michael J., Camporez‎, João-Paulo G., Alves, Tiago C., Kahn, Mario, Guigni, Blas A., Serr, Julie, Zhang, Dongyan, Bhanot, Sanjay, Samuel, Varman T., Shulman, Gerald I.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3732992/
https://ncbi.nlm.nih.gov/pubmed/23840067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1311176110
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