Ablation of Dihydroceramide Desaturase Confers Resistance to Etoposide-Induced Apoptosis In Vitro

Sphingolipid biosynthesis is potently upregulated by factors associated with cellular stress, including numerous chemotherapeutics, inflammatory cytokines, and glucocorticoids. Dihydroceramide desaturase 1 (Des1), the third enzyme in the highly conserved pathway driving sphingolipid biosynthesis, in...

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Detalhes bibliográficos
Main Authors: Siddique, Monowarul M., Bikman, Benjamin T., Wang, Liping, Ying, Li, Reinhardt, Erin, Shui, Guanghou, Wenk, Markus R., Summers, Scott A.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3439484/
https://ncbi.nlm.nih.gov/pubmed/22984457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0044042
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