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Enzymatic Degradation of A2E, a Retinal Pigment Epithelial Lipofuscin Bisretinoid

[Image: see text] Some forms of blinding macular disease are associated with excessive accumulation of bisretinoid lipofuscin in retinal pigment epithelial (RPE) cells of the eye. This material is refractory to lysosomal enzyme degradation. In addition to gene and drug-based therapies, treatments th...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Wu, Yalin, Zhou, Jilin, Fishkin, Nathan, Rittmann, Bruce E., Sparrow, Janet R.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2011
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4112458/
https://ncbi.nlm.nih.gov/pubmed/21166406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja107195u
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