CTCF prevents genomic instability by promoting homologous recombination-directed DNA double-strand break repair

CTCF is an essential epigenetic regulator mediating chromatin insulation, long-range regulatory interactions, and the organization of large topological domains in the nucleus. Phenotypes of CTCF haploinsufficient mutations in humans, knockout in mice, and depletion in cells are often consistent with...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Lang, Fengchao, Li, Xin, Zheng, Wenhai, Li, Zhuoran, Lu, Danfeng, Chen, Guijun, Gong, Daohua, Yang, Liping, Fu, Jinlin, Shi, Peng, Zhou, Jumin
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2017
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5642685/
https://ncbi.nlm.nih.gov/pubmed/28973861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1704076114
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