CTCF prevents genomic instability by promoting homologous recombination-directed DNA double-strand break repair

CTCF is an essential epigenetic regulator mediating chromatin insulation, long-range regulatory interactions, and the organization of large topological domains in the nucleus. Phenotypes of CTCF haploinsufficient mutations in humans, knockout in mice, and depletion in cells are often consistent with...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Lang, Fengchao, Li, Xin, Zheng, Wenhai, Li, Zhuoran, Lu, Danfeng, Chen, Guijun, Gong, Daohua, Yang, Liping, Fu, Jinlin, Shi, Peng, Zhou, Jumin
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2017
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5642685/
https://ncbi.nlm.nih.gov/pubmed/28973861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1704076114
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