CTCF prevents genomic instability by promoting homologous recombination-directed DNA double-strand break repair

CTCF is an essential epigenetic regulator mediating chromatin insulation, long-range regulatory interactions, and the organization of large topological domains in the nucleus. Phenotypes of CTCF haploinsufficient mutations in humans, knockout in mice, and depletion in cells are often consistent with...

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Bibliografski detalji
Izdano u:Proc Natl Acad Sci U S A
Glavni autori: Lang, Fengchao, Li, Xin, Zheng, Wenhai, Li, Zhuoran, Lu, Danfeng, Chen, Guijun, Gong, Daohua, Yang, Liping, Fu, Jinlin, Shi, Peng, Zhou, Jumin
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2017
Teme:
Biological Sciences
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5642685/
https://ncbi.nlm.nih.gov/pubmed/28973861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1704076114
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