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Addressing the Metabolic Stability of Antituberculars through Machine Learning
[Image: see text] We present the first prospective application of our mouse liver microsomal (MLM) stability Bayesian model. CD117, an antitubercular thienopyrimidine tool compound that suffers from metabolic instability (MLM t(1/2) < 1 min), was utilized to assess the predictive power of our new...
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| Pubblicato in: | ACS Med Chem Lett |
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| Autori principali: | , , , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Chemical
Society
2017
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| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5642018/ https://ncbi.nlm.nih.gov/pubmed/29057058 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.7b00299 |
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