Addressing the Metabolic Stability of Antituberculars through Machine Learning

[Image: see text] We present the first prospective application of our mouse liver microsomal (MLM) stability Bayesian model. CD117, an antitubercular thienopyrimidine tool compound that suffers from metabolic instability (MLM t(1/2) < 1 min), was utilized to assess the predictive power of our new...

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Udgivet i:ACS Med Chem Lett
Main Authors: Stratton, Thomas P., Perryman, Alexander L., Vilchèze, Catherine, Russo, Riccardo, Li, Shao-Gang, Patel, Jimmy S., Singleton, Eric, Ekins, Sean, Connell, Nancy, Jacobs, William R., Freundlich, Joel S.
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2017
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5642018/
https://ncbi.nlm.nih.gov/pubmed/29057058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.7b00299
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