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Evolution of a thienopyrimidine antitubercular relying on medicinal chemistry and metabolomics insights()

The metabolic instability of an antitubercular small molecule CD117 was addressed through iterative alteration of a key sulfide substituent and interrogation of the effect on growth inhibition of cultured Mycobacterium tuberculosis. This process was informed by studies of the intramycobacterial meta...

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Bibliografiske detaljer
Udgivet i:Tetrahedron Lett
Main Authors: Li, Shao-Gang, Vilchèze, Catherine, Chakraborty, Sumit, Wang, Xin, Kim, Hiyun, Anisetti, Monica, Ekins, Sean, Rhee, Kyu Y., Jacobs, William R., Freundlich, Joel S.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4527344/
https://ncbi.nlm.nih.gov/pubmed/26257441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tetlet.2015.02.129
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