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Evolution of a thienopyrimidine antitubercular relying on medicinal chemistry and metabolomics insights()
The metabolic instability of an antitubercular small molecule CD117 was addressed through iterative alteration of a key sulfide substituent and interrogation of the effect on growth inhibition of cultured Mycobacterium tuberculosis. This process was informed by studies of the intramycobacterial meta...
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| Veröffentlicht in: | Tetrahedron Lett |
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| Hauptverfasser: | , , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2015
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4527344/ https://ncbi.nlm.nih.gov/pubmed/26257441 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tetlet.2015.02.129 |
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