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Predicting Mouse Liver Microsomal Stability with “Pruned” Machine Learning Models and Public Data
PURPOSE: Mouse efficacy studies are a critical hurdle to advance translational research of potential therapeutic compounds for many diseases. Although mouse liver microsomal (MLM) stability studies are not a perfect surrogate for in vivo studies of metabolic clearance, they are the initial model sys...
Gardado en:
| Publicado en: | Pharm Res |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2015
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4712113/ https://ncbi.nlm.nih.gov/pubmed/26415647 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-015-1800-5 |
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