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Predicting Mouse Liver Microsomal Stability with “Pruned” Machine Learning Models and Public Data

PURPOSE: Mouse efficacy studies are a critical hurdle to advance translational research of potential therapeutic compounds for many diseases. Although mouse liver microsomal (MLM) stability studies are not a perfect surrogate for in vivo studies of metabolic clearance, they are the initial model sys...

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Detalhes bibliográficos
Publicado no:Pharm Res
Main Authors: Perryman, Alexander L., Stratton, Thomas P., Ekins, Sean, Freundlich, Joel S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4712113/
https://ncbi.nlm.nih.gov/pubmed/26415647
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-015-1800-5
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