Novel Pyrimidines as Antitubercular Agents

Mycobacterium tuberculosis infection is responsible for a global pandemic. New drugs are needed that do not show cross-resistance with the existing front-line therapeutics. A triazine antitubercular hit led to the design of a related pyrimidine family. The synthesis of a focused series of these anal...

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Bibliographic Details
Published in:Antimicrob Agents Chemother
Main Authors: Inoyama, Daigo, Paget, Steven D., Russo, Riccardo, Kandasamy, Srinivasan, Kumar, Pradeep, Singleton, Eric, Occi, James, Tuckman, Margareta, Zimmerman, Matthew D., Ho, Hsin Pin, Perryman, Alexander L., Dartois, Véronique, Connell, Nancy, Freundlich, Joel S.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2018
Subjects:
Experimental Therapeutics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5826157/
https://ncbi.nlm.nih.gov/pubmed/29311070
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02063-17
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