Phosphorylation of the FUS low‐complexity domain disrupts phase separation, aggregation, and toxicity

Neuronal inclusions of aggregated RNA‐binding protein fused in sarcoma (FUS) are hallmarks of ALS and frontotemporal dementia subtypes. Intriguingly, FUS's nearly uncharged, aggregation‐prone, yeast prion‐like, low sequence‐complexity domain (LC) is known to be targeted for phosphorylation. Her...

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Bibliografski detalji
Izdano u:EMBO J
Glavni autori: Monahan, Zachary, Ryan, Veronica H, Janke, Abigail M, Burke, Kathleen A, Rhoads, Shannon N, Zerze, Gül H, O'Meally, Robert, Dignon, Gregory L, Conicella, Alexander E, Zheng, Wenwei, Best, Robert B, Cole, Robert N, Mittal, Jeetain, Shewmaker, Frank, Fawzi, Nicolas L
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2017
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Articles
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5641905/
https://ncbi.nlm.nih.gov/pubmed/28790177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201696394
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