Phosphorylation of the FUS low‐complexity domain disrupts phase separation, aggregation, and toxicity

Neuronal inclusions of aggregated RNA‐binding protein fused in sarcoma (FUS) are hallmarks of ALS and frontotemporal dementia subtypes. Intriguingly, FUS's nearly uncharged, aggregation‐prone, yeast prion‐like, low sequence‐complexity domain (LC) is known to be targeted for phosphorylation. Her...

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Publicado en:EMBO J
Autores principales: Monahan, Zachary, Ryan, Veronica H, Janke, Abigail M, Burke, Kathleen A, Rhoads, Shannon N, Zerze, Gül H, O'Meally, Robert, Dignon, Gregory L, Conicella, Alexander E, Zheng, Wenwei, Best, Robert B, Cole, Robert N, Mittal, Jeetain, Shewmaker, Frank, Fawzi, Nicolas L
Formato: Artigo
Lenguaje:Inglês
Publicado: John Wiley and Sons Inc. 2017
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Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5641905/
https://ncbi.nlm.nih.gov/pubmed/28790177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201696394
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