ALS mutations disrupt phase separation mediated by -helical structure in the TDP-43 low complexity C-terminal domain

RNA-binding protein TDP-43 mediates essential RNA processing but forms cytoplasmic neuronal inclusions via its C-terminal domain (CTD) in amyotrophic lateral sclerosis (ALS). It remains unclear if aggregated TDP-43 is neurotoxic and if ~50 ALS-associated missense mutations in TDP-43 CTD promote aggr...

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Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:Structure
Asıl Yazarlar: Conicella, Alexander E., Zerze, Gül H., Mittal, Jeetain, Fawzi, Nicolas L.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2016
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5014597/
https://ncbi.nlm.nih.gov/pubmed/27545621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2016.07.007
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