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ALS mutations disrupt phase separation mediated by -helical structure in the TDP-43 low complexity C-terminal domain
RNA-binding protein TDP-43 mediates essential RNA processing but forms cytoplasmic neuronal inclusions via its C-terminal domain (CTD) in amyotrophic lateral sclerosis (ALS). It remains unclear if aggregated TDP-43 is neurotoxic and if ~50 ALS-associated missense mutations in TDP-43 CTD promote aggr...
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| Publicado no: | Structure |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5014597/ https://ncbi.nlm.nih.gov/pubmed/27545621 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2016.07.007 |
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