A single N‐terminal phosphomimic disrupts TDP‐43 polymerization, phase separation, and RNA splicing

TDP‐43 is an RNA‐binding protein active in splicing that concentrates into membraneless ribonucleoprotein granules and forms aggregates in amyotrophic lateral sclerosis (ALS) and Alzheimer's disease. Although best known for its predominantly disordered C‐terminal domain which mediates ALS inclu...

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Gepubliceerd in:EMBO J
Hoofdauteurs: Wang, Ailin, Conicella, Alexander E, Schmidt, Hermann Broder, Martin, Erik W, Rhoads, Shannon N, Reeb, Ashley N, Nourse, Amanda, Ramirez Montero, Daniel, Ryan, Veronica H, Rohatgi, Rajat, Shewmaker, Frank, Naik, Mandar T, Mittag, Tanja, Ayala, Yuna M, Fawzi, Nicolas L
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: John Wiley and Sons Inc. 2018
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5830921/
https://ncbi.nlm.nih.gov/pubmed/29438978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201797452
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