Detection of TAR DNA-binding protein 43 (TDP-43) oligomers as initial intermediate species during aggregate formation

Aggregates of the RNA-binding protein TDP-43 (TAR DNA-binding protein) are a hallmark of the overlapping neurodegenerative disorders amyotrophic lateral sclerosis (ALS) and frontotemporal dementia. The process of TDP-43 aggregation remains poorly understood, and whether it includes formation of inte...

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Veröffentlicht in:J Biol Chem
Hauptverfasser: French, Rachel L., Grese, Zachary R., Aligireddy, Himani, Dhavale, Dhruva D., Reeb, Ashley N., Kedia, Niraja, Kotzbauer, Paul T., Bieschke, Jan, Ayala, Yuna M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2019
Schlagworte:
Neurobiology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6497947/
https://ncbi.nlm.nih.gov/pubmed/30824544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.005889
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