Molecular interactions underlying liquid-liquid phase separation of the FUS low complexity domain

The low complexity domain of the RNA-binding protein FUS (FUS LC) mediates liquid-liquid phase separation (LLPS), but interactions between the repetitive SYGQ-rich sequence of FUS LC that stabilize the liquid phase are not known in detail. By combining NMR and Raman spectroscopy, mutagenesis, and mo...

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Gepubliceerd in:Nat Struct Mol Biol
Hoofdauteurs: Murthy, Anastasia C., Dignon, Gregory L., Kan, Yelena, Zerze, Gül H., Parekh, Sapun H., Mittal, Jeetain, Fawzi, Nicolas L.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2019
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6613800/
https://ncbi.nlm.nih.gov/pubmed/31270472
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41594-019-0250-x
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