Overexpression of tissue-nonspecific alkaline phosphatase (TNAP) in endothelial cells accelerates coronary artery disease in a mouse model of familial hypercholesterolemia

OBJECTIVE: Overexpression of tissue-nonspecific alkaline phosphatase (TNAP) in endothelium leads to arterial calcification in mice. The purpose of this study was to examine the effect of elevated endothelial TNAP on coronary atherosclerosis. In addition, we aimed to examine endogenous TNAP activity...

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Publicado en:PLoS One
Main Authors: Romanelli, Filippo, Corbo, AnthonyMarco, Salehi, Maryam, Yadav, Manisha C., Salman, Soha, Petrosian, David, Rashidbaigi, Omid J., Chait, Jesse, Kuruvilla, Jes, Plummer, Maria, Radichev, Ilian, Margulies, Kenneth B., Gerdes, A. Martin, Pinkerton, Anthony B., Millán, José Luis, Savinov, Alexei Y., Savinova, Olga V.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2017
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5638543/
https://ncbi.nlm.nih.gov/pubmed/29023576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0186426
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