Overexpression of tissue-nonspecific alkaline phosphatase (TNAP) in endothelial cells accelerates coronary artery disease in a mouse model of familial hypercholesterolemia

OBJECTIVE: Overexpression of tissue-nonspecific alkaline phosphatase (TNAP) in endothelium leads to arterial calcification in mice. The purpose of this study was to examine the effect of elevated endothelial TNAP on coronary atherosclerosis. In addition, we aimed to examine endogenous TNAP activity...

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Pubblicato in:PLoS One
Autori principali: Romanelli, Filippo, Corbo, AnthonyMarco, Salehi, Maryam, Yadav, Manisha C., Salman, Soha, Petrosian, David, Rashidbaigi, Omid J., Chait, Jesse, Kuruvilla, Jes, Plummer, Maria, Radichev, Ilian, Margulies, Kenneth B., Gerdes, A. Martin, Pinkerton, Anthony B., Millán, José Luis, Savinov, Alexei Y., Savinova, Olga V.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2017
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5638543/
https://ncbi.nlm.nih.gov/pubmed/29023576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0186426
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