Discovery of 5-((5-chloro-2-methoxyphenyl)sulfonamido)nicotinamide (SBI-425), a potent and orally bioavailable tissue-nonspecific alkaline phosphatase (TNAP) inhibitor

Tissue-nonspecific alkaline phosphatase (TNAP) is an ectoenzyme crucial for bone matrix mineralization via its ability to hydrolyze extracellular inorganic pyrophosphate (ePP(i)), a potent mineralization inhibitor, to phosphate (P(i)). By the controlled hydrolysis of ePP(i), TNAP maintains the corre...

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Detalhes bibliográficos
Publicado no:Bioorg Med Chem Lett
Main Authors: Pinkerton, Anthony B., Sergienko, Eduard, Bravo, Yalda, Dahl, Russell, Ma, Chen-Ting, Sun, Qing, Jackson, Michael R., Cosford, Nicholas D. P., Millán, José Luis
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5731646/
https://ncbi.nlm.nih.gov/pubmed/29174347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2017.11.024
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