Discovery and Validation of a Series of Aryl Sulfonamides as Selective Inhibitors of Tissue-Nonspecific Alkaline Phosphatase (TNAP)

We report the characterization and optimization of drug-like small molecule inhibitors of tissue-nonspecific alkaline phosphatase (TNAP), an enzyme critical for the regulation of extracellular matrix calcification during bone formation and growth. High-throughput screening (HTS) of a small molecule...

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Bibliographic Details
Main Authors:	Dahl, Russell, Sergienko, Eduard A., Mostofi, Yalda S., Yang, Li, Su, Ying, Simao, Ana Maria, Narisawa, Sonoko, Brown, Brock, Mangravita-Novo, Arianna, Vicchiarelli, Michael, Smith, Layton H., O’Neill, W. Charles, Millán, José Luis, Cosford, Nicholas D. P.
Format:	Artigo
Language:	Inglês
Published:	2009
Subjects:	Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC2783186/ https://ncbi.nlm.nih.gov/pubmed/19821572 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm900383s
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Discovery and Validation of a Series of Aryl Sulfonamides as Selective Inhibitors of Tissue-Nonspecific Alkaline Phosphatase (TNAP)

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