Design and synthesis of pyrazole derivatives as potent and selective inhibitors of tissue-nonspecific alkaline phosphatase (TNAP)

Tissue-nonspecific alkaline phosphatase (TNAP) plays a central role in regulating extracellular matrix calcification during bone formation and growth. High throughput screening (HTS) for small molecule TNAP inhibitors led to the identification of hits in the sub-micromolar potency range. We report t...

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Bibliographic Details
Main Authors: Sidique, Shyama, Ardecky, Robert, Su, Ying, Narisawa, Sonoko, Brown, Brock, Millán, José Luis, Sergienko, Eduard, Cosford, Nicholas D. P.
Format: Artigo
Language:Inglês
Published: 2008
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2752324/
https://ncbi.nlm.nih.gov/pubmed/19038545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2008.10.107
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