Functional Significance of Calcium Binding to Tissue-Nonspecific Alkaline Phosphatase

The conserved active site of alkaline phosphatases (AP) contains catalytically important Zn(2+) (M1 and M2) and Mg(2+)-sites (M3) and a fourth peripheral Ca(2+) site (M4) of unknown significance. We have studied Ca(2+) binding to M1-4 of tissue-nonspecific AP (TNAP), an enzyme crucial for skeletal m...

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Pubblicato in:PLoS One
Autori principali: Hoylaerts, Marc F., Van kerckhoven, Soetkin, Kiffer-Moreira, Tina, Sheen, Campbell, Narisawa, Sonoko, Millán, José Luis
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2015
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4361680/
https://ncbi.nlm.nih.gov/pubmed/25775211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0119874
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