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In Vivo Overexpression of Tissue-Nonspecific Alkaline Phosphatase Increases Skeletal Mineralization and Affects the Phosphorylation Status of Osteopontin

Functional ablation of tissue-nonspecific alkaline phosphatase (TNAP) (Alpl(−/−) mice) leads to hypophosphatasia, characterized by rickets/osteomalacia attributable to elevated levels of extracellular inorganic pyrophosphate, a potent mineralization inhibitor. Osteopontin (OPN) is also elevated in t...

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Detalhes bibliográficos
Main Authors: Narisawa, Sonoko, Yadav, Manisha C., Millán, José Luis
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3688694/
https://ncbi.nlm.nih.gov/pubmed/23427088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jbmr.1901
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