Tissue-nonspecific alkaline phosphatase and plasma cell membrane glycoprotein-1 are central antagonistic regulators of bone mineralization

Osteoblasts mineralize bone matrix by promoting hydroxyapatite crystal formation and growth in the interior of membrane-limited matrix vesicles (MVs) and by propagating the crystals onto the collagenous extracellular matrix. Two osteoblast proteins, tissue-nonspecific alkaline phosphatase (TNAP) and...

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Autors principals: Hessle, Lovisa, Johnson, Kristen A., Anderson, H. Clarke, Narisawa, Sonoko, Sali, Adnan, Goding, James W., Terkeltaub, Robert, Millán, José Luis
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2002
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC123160/
https://ncbi.nlm.nih.gov/pubmed/12082181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.142063399
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