Loss of Skeletal Mineralization by the Simultaneous Ablation of PHOSPHO1 and Alkaline Phosphatase Function: A Unified Model of the Mechanisms of Initiation of Skeletal Calcification

Endochondral ossification is a carefully orchestrated process mediated by promoters and inhibitors of mineralization. Phosphatases are implicated, but their identities and functions remain unclear. Alkaline phosphatase (TNAP) plays a crucial role promoting mineralization of the extracellular matrix...

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Detalhes bibliográficos
Main Authors: Yadav, Manisha C, Simão, Ana Maria Sper, Narisawa, Sonoko, Huesa, Carmen, McKee, Marc D, Farquharson, Colin, Millán, José Luis
Formato: Artigo
Idioma:Inglês
Publicado em: Wiley Subscription Services, Inc., A Wiley Company 2011
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3179344/
https://ncbi.nlm.nih.gov/pubmed/20684022
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jbmr.195
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