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Ablation of Osteopontin Improves the Skeletal Phenotype of Phospho1−/− Mice
PHOSPHO1 and tissue-nonspecific alkaline phosphatase (TNAP) have nonredundant functions during skeletal mineralization. Although TNAP deficiency (Alpl(−/−) mice) leads to hypophosphatasia, caused by accumulation of the mineralization inhibitor inorganic pyrophosphate (PP(i)), comparably elevated lev...
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| Pubblicato in: | J Bone Miner Res |
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| Autori principali: | , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2014
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5247257/ https://ncbi.nlm.nih.gov/pubmed/24825455 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jbmr.2281 |
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