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Ablation of Osteopontin Improves the Skeletal Phenotype of Phospho1−/− Mice

PHOSPHO1 and tissue-nonspecific alkaline phosphatase (TNAP) have nonredundant functions during skeletal mineralization. Although TNAP deficiency (Alpl(−/−) mice) leads to hypophosphatasia, caused by accumulation of the mineralization inhibitor inorganic pyrophosphate (PP(i)), comparably elevated lev...

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Bibliografiske detaljer
Udgivet i:J Bone Miner Res
Main Authors: Yadav, Manisha C, Huesa, Carmen, Narisawa, Sonoko, Hoylaerts, Marc F, Moreau, Alain, Farquharson, Colin, Millán, José Luis
Format: Artigo
Sprog:Inglês
Udgivet: 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5247257/
https://ncbi.nlm.nih.gov/pubmed/24825455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jbmr.2281
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