Skeletal mineralization deficits and impaired biogenesis and function of chondrocyte-derived matrix vesicles in Phospho1(−/−) and Phospho1/Pit1 double knockout mice

We have previously shown that ablation of either the Phospho1 or Alpl gene, encoding PHOSPHO1 and tissue-nonspecific alkaline phosphatase (TNAP) respectively, lead to hyperosteoidosis but that their chondrocyte- and osteoblast-derived matrix vesicles (MVs) are able to initiate mineralization. In con...

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Udgivet i:J Bone Miner Res
Main Authors: Yadav, Manisha C., Bottini, Massimo, Cory, Esther, Bhattacharya, Kunal, Kuss, Pia, Narisawa, Sonoko, Sah, Robert L., Beck, Laurent, Fadeel, Bengt, Farquharson, Colin, Millán, José Luis
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4891278/
https://ncbi.nlm.nih.gov/pubmed/26773408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jbmr.2790
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