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In Vivo Overexpression of Tissue-Nonspecific Alkaline Phosphatase Increases Skeletal Mineralization and Affects the Phosphorylation Status of Osteopontin
Functional ablation of tissue-nonspecific alkaline phosphatase (TNAP) (Alpl(−/−) mice) leads to hypophosphatasia, characterized by rickets/osteomalacia attributable to elevated levels of extracellular inorganic pyrophosphate, a potent mineralization inhibitor. Osteopontin (OPN) is also elevated in t...
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| Главные авторы: | , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2013
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3688694/ https://ncbi.nlm.nih.gov/pubmed/23427088 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jbmr.1901 |
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